This research has been developed by Martin Levine Ph.D.
Lysine Decarboxylase Inhibitors for Prevention and Treatment of Periodontal Disease
Inflammatory adult periodontal diseases are the primary cause of tooth loss, and therefore a major source of dental problems, in the middle aged and elderly. They consist of gingival inflammation (gingivitis) and tooth attachment loss (periodontitis) which are currently treated by intensive oral hygiene and surgery if required. The outcome of therapy is unpredictable.
The inventors have developed agents which abolish the expression or activity of lysine decarboxylase, slowing the initial development of a pathogenic flora protecting the patient from periodontal disease. The agents may be incorporated into toothpastes and periodontal treatment packs or the purified enzyme could provide a vaccine for inducing antibodies which neutralize the enzymatic activity in the sulcus.
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This technology has been licensed and is not available.