This research has been developed by Courtney Houchen M.D., Randal May, Shrikant Anant Ph.D., James Wyche Ph.D., Zhiyong Han
Method of targeted depletion of gastrointestinal and cancer stem cells
Colorectal cancers arise from stem cells, located near the base of intestinal and colonic crypts. Only a few cells however, within the tumors, are stem cells. Identifying gut stem cells is difficult, because no definitive intestinal stem cell markers are known. We have identified a putative stem cell marker which is expressed in post-mitotic neurons, that was recently isolated from small intestinal and gastric epithelial progenitor populations.
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